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Psychedelic Definition & Meaning That is, pretreatment with the phosphoinositide 3-kinase inhibitor LY (2-morpholin-4-yl-8-phenylchromen-4-one) prevented serotonin-induced phosphorylation of Akt in WT neurons, as did treatment with the Src inhibitor PP2 [4-amino-5-(4-chlorophenyl)-7-pyrazolo[3,4-d]pyrimidine]. Several studies have shown that rapid tolerance to psychedelics correlates with downregulation of 5-HT2A receptors. For example, daily LSD administration selectively decreased 5-HT2 receptor density in the rat brain (Buckholtz et al., 1985, 1990). The patients suffered from depression or AD, with three of the AD patients also having concurrent depression. Meltzer et al. reported finding no reduction in altanserin binding in depressed patients, and no effect of depression on binding in the AD group. By contrast, the AD patients had significantly lower 5-HT2A binding potential in several brain regions, Psychedelics compared with controls. These regions included the ACC, PFC